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Although the human body still contains many mysteries, scientists have managed to solve one of them; that the lungs play a key role in the production of blood. To date, the task of producing blood was a task of bone marrow. But studies at the University of California San Francisco (UCSF) showed that; Most of the body's platelet cells are produced in the lungs. That is, when the stockpiles in the bone marrow dry, the lungs can be used for blood stem cell reserve.
Scientists have long believed that most of the cells that make up the blood are produced in the bone marrow. This process is called hematopoiesis, red blood cells carrying oxygen, white blood cells fighting against infections and other components such as platelets (stopping bleeding) were produced in this way. Although platelet-producing cells such as megakaryocytes were seen in lung tissue before, these cells were generally thought to live in bone marrow. Here at the University of California San Francisco, a study of mouse lung imaging showed the interaction of thrombocytes in the lungs and their interaction with the immune system. In the examined mice, the platelets were expected to glow green, but the lungs were illuminated with an incredible number of megakaryocytes. Ik When we discovered megakaryocytes in this huge population in the lungs, we understood that we should follow it, bu says Emma Lefrançais, co-author of the study. In close examination, he found that megakaryocytes in the lungs produced millions of platelets per hour, which was about half the total amount of mice. Immediately, the population in the vasculature of the lung (veins) is fed by megakaryocyte progenitor cells and blood stem cells. The team detected about 1 million cells per lung with a video microscope. Or These findings give a sophisticated perspective on the lungs - they play an important role not only for breathing but also for blood production. This observation, which I did on mice, also supports the fact that lungs play an important role in blood production in humans, says Mark R. Looney, the senior author of the study.

Lung and Bone Marrow Working Together in Blood Production
Lungs and bone marrow seem to be; working together to produce blood. In the study, blood stem cells were placed in animals with fluorescent megakaryocytes, taking lungs from normal mice to show that they went up and down between the bone marrow and the lungs. Soon the cells began to shine in normal lung vasculature. Although there are more megarkaryocytes in the lungs, they are still born in the bone before migration. Lar This is really fascinating, and megakaryocytes travel from the bone marrow to the lungs, producing platelets. Probably because of the mechanical strength of the blood, the lungs are the ideal bioreactor for platelet production, or perhaps there are some molecular signals that we still don't know, osit says Guadalupe Ortiz-Muñoz. The fluorescently labeled fluorescent megakaryocyte lungs were placed in the mouse with a low platelet count. The mouse's thrombocytes increased rapidly to a healthy level. In a recent study, the team investigated how lung megakaryocytes could remove this burden when the megakaryocytes in the bone marrow did not function. They transplanted the fluorescently labeled lungs to the mouse with a bone marrow without blood stem cells. After a while, the lungs helped not only produce platelets in the bone marrow, but also cells such as neutrophils, B cells and T cells. Ey While this is the first description that blood progenitors live in the lungs, millions of thrombocytopenia will raise questions about their patients, ler says Looney. We see that more and more stem cells produce blood and move on to the blood stream without being bound to a place. Perhaps different organs are a normal part of stem cell training. The findings will lead to new research in understanding the diseases affecting platelet production. In the future, how the lungs and bone marrow in the human body produce blood together can be explored through this discovery. The research was published in Nature.

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