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According to a study published in the journal Science, British scientists have discovered that lung cancers can sleep for more than 20 years before becoming suddenly aggressive. The research team worked on 7 cancer patients, including people who smoked, quit smoking and never smoked. After the first genetic mutation causing cancer, they discovered that new additional mutations could wait silent and insidiously for many years without being detected.
During this progression, a number of different genetic errors are being observed in separate regions of the tumor. Every independent region is evolving in different ways. This shows that each part of the tumor is genetically unique. Co-financed by the UK-UK Cancer Research Authority and Rosetrees Trust, the study draws attention to the need for better methods to diagnose the disease earlier. Because two-thirds of patients are diagnosed in advanced forms, where treatment is often unsuccessful.

Researchers hope to improve the early diagnosis of the disease, indicating that lung cancers can remain on hold for many years. The author of the study was Prof. Dr. at the London Research Institute of Cancer Research. . The likelihood of getting out of lung cancer is very low as a result of the limited impact of targeted new treatments. As a result of our understanding of the development of the disease, we have opened the evolutionary rule book of the disease in the hope of predicting the next step. Hast The study also points to the importance of smoking in the development of lung cancer. Most of the early genetic errors occur due to smoking. Since the tumor controlled by the APOBEC protein creates new mutations, the magnitude of these errors does not affect the disease that is evolving. The discovery of a wide range of genetic errors has shown why the success of targeted treatments is limited. Moving to a specific genetic error defined by the biopsy is only effective against the part of the tumor that occurs as a result of the error. Other regions continue their lives and take control. More than 40,000 people are diagnosed with lung cancer every year. Although some positive steps have been taken against the disease, the survival rate of 5 years after diagnosis is less than 10%, the reason for Lung cancer remains the biggest problem for cancer research. Continuing work on this research will be the primary target of the recently established UK Cancer Research - Lung Cancer Center. This center, in which Professor Schanton joins as manager, has become an environment that accelerates the research of creative and innovative lung cancer by bringing together the famous scientists and clinicians of all areas to defeat lung cancer in the UK Cancer Research. President of the UK Cancer Research . This fascinating research has shown the need to find better methods to detect lung cancer at the moment of an evolutionary pathway. If we take the lead in the beginning of the disease and treat it without turning to different evolutionary routes, we will make a significant difference for the survival of our patients. Yeni On top of that, the UK Cancer Research Agency has funded a new study called TRACERx to study the hundreds of lung cancers to find out how the disease has evolved over time and how it has mutated, adapted, and resisted treatment. ‘

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