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Researchers from the Salk Institute have discovered that a drug they developed for the treatment of Alzheimer's has anti-aging effects. In addition to Alzheimer's treatment, the J147 Alzheimer's drug candidate developed by the Salk team improved the physiological properties by improving blood flow in the vessels. Mice treated with J 147 were reported to have improved memory and cognitive activity.
The findings published in the journal Aging were shared with the scientific community. To test the strength of the drug at the beginning, we used the animal model, which is 99% compatible with Alzheimer's cases. But we didn't expect the drug to have such an anti-aging effect. Thanks to the drug J 147, old rats began to appear as young rats, exhibiting physiological parameters, 147 said Salk Cell Neurobiology Laboratory. David Schubert.
Alzheimer's disease is a progressive disease, and the third cause of death in the United States. According to NIH, it is one of the biggest causes of dementia, especially in the elderly. Man Most of the drugs developed over the last 20 years have targeted amyloid plate deposition in the brain, but none of the clinics have proven to be effective, “said the author. Schubert.

Only a few years ago, Schubert and his colleagues followed a different perspective in the treatment of the disease. Instead of amyloid plaques, the main factor in the disease was aging. J147 was synthesized by using brain-based brain toxins using cell-based imaging. They found J147 in an inherited mouse model known to stop or even reverse memory loss. Nonetheless, this form represents only 1% of Alzheimer's disease. Of course, the most important factor here is aging. After the team, people tried the drug as a mouse that resembles the aging model and rapidly aging and aging. In the final study, the brain tested in a set of all genes, three small groups of brain metabolism and rapidly aging in three groups of mice tested. The first set included young mice, aged mice in the second set, and mice given J147 in the third set.
J147 showed better and more stable behavior in mouse memory and cognitive tests and also in motor movements. Very few pathological signs of Alzheimer's were observed in mice given J147. In mice given J147 gene expression and metabolism in terms of very similar to young animals were detected. Increased metabolism energy, decreased brain inflammation and reduced oxidized fatty acid ratio in the brain. Another significant effect was the prevention of blood leakage from capillaries in aged mice. Damage to Alzheimer's vessels is a common feature. Ub If J147's anti-aging and Alzheimer effect is proven to be reliable, it can benefit, 14 says Schubert. Human trials will begin next year.

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